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Very early ARV treatment of HIV+ infants slows progression of virus

Any Type of ARV Treatment From Birth Can Delay Onset of AIDS

Mots-Clés / ARV

Kaiser Network 11/May/05

Administering anti-retroviral (ARV  ) treatment to very young, HIV-positive infants, especially when treatment starts before the age of three months, decreases the chance they will progress to the "advanced stage" of the virus by the age of three years, according to a study published in the May issue of the Journal of the American Medical Association.

Dr David Berk of the Stanford School of Medicine and colleagues from the California Paediatric HIV Study Group examined the medical records of 205 HIV-positive infants born in Northern California between 1988 and 2001. Of the 205 children who were monitored until the age of three ; about 65 per cent received ARV   therapy and/or pneumonia prophylaxis. By the age of three, 81 of the children had progressed to an AIDS diagnosis, and 41 of those children had died.

Untreated children were significantly more likely to progress to an advanced stage of virus, compared with children who received treatment. Overall, about 62 per cent of the untreated children who were studied progressed to an advanced stage of HIV, compared with 28 per cent of treated children.

After dividing the children into three groups based on their year of birth, the researchers found that none of the HIV-positive children born from 1996 to 2001 who received a daily regimen of at least three ARVs died before age three, but about 55 per cent of children born from 1988 to 1991 and 1992 to 1995, when combination ARV   treatment was not widely used, died before the age of three.

Although children who received a three-drug combination experienced slower virus progression, the researchers found that any type of ARV   treatment delayed the onset of AIDS and increased survival time.

Publié sur OSI Bouaké le dimanche 15 mai 2005




> Very early ARV treatment of HIV+ infants slows progression of virus
14 mai 2005, par Sand   [retour au début des forums]

Avis aux contributeurs potentiels (qui se battent pour prendre la parole sur ce blog !) : nous cherchons à documenter la question de l’accès aux ARV   pour les enfants VIH  +, en particulier dans les pays du Sud. Toutes les informations sur le sujet seront bienvenues.

> Very early ARV treatment of HIV+ infants slows progression of virus
14 mai 2005, par didier   [retour au début des forums]

C’est en effet une préoccupation majeure de l’ensemble des participants à ce blog !